I could see a serial loader handy for an ISP upgrade on a supported game or to test code using a RAM Cart (or just the onboard WRAM), but those of us with access to CopyNES hardware, or the capital to invest in one most likely already have a tool (or several
Speaking of CopyNES, I remember the technical description explaining that CopyNES sits in what is normally mirrored memory space. I could see it benefitial to have the code here do a similar thing upon startup (point reset vector, run code in mirrored memory gone ROM). Once booting to cartridge, the ROM would be disabled and could remain compatible with existing carts, or could check for a 'compatible' ROM header and stay resident.
The onboard VRAM could probably be further mirrored for the CHR-RAM if economical (a la Magic Floor). Again this would be disabled on cartridge start, but could be handy for cart free WRAM loading.
If the POST detects a cartridge, showing a (FamicomBox) game title would be nice (if available).